31 articles - From Saturday Jan 22 2022 to Friday Jan 28 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Blocking GM-CSF receptor a with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients with giant cell arteritis. The inhibitory effects of mavrilimumab on multiple steps in the GCA pathogenesis cascade in vitro are consistent with the clinical observation of reduced GCA flares in a phase 2 trial and support its development as a therapeutic option for patients with GCA. |
EULAR points to consider when analysing and reporting comparative effectiveness research using observational data in rheumatology. To improve the reliability of an increasing number of real-world comparative effectiveness studies in rheumatology, special attention is required to reduce potential biases. Adherence to clear recommendations for the analysis and reporting of observational comparative effectiveness studies will improve the trustworthiness of their results. |
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7. Methods F-box and WD repeat domain containing 7 (FBXW7) ubiquitin ligase expression and chondrocyte senescence were examined in vitro, in experimental OA mice and in human OA cartilage. Mice with mRNA transcription and FBXW7-mediated MKK7 degradation, which consequently stimulated JNK signalling. In particular, inhibition of JNK activity by DTP3, a MKK7 inhibitor, ameliorated chondrocyte senescence and cartilage degeneration CONCLUSIONS: FBXW7 is a key factor in the association between mechanical overloading and chondrocyte senescence and cartilage ageing in the pathology of OA. |
| Arthritis Res Ther |
"The medications are the decision-makers…" Making reproductive and medication use decisions among female patients with rheumatoid arthritis: a constructivist grounded theory. Our framework provides insight into how patients make reproductive decisions in the context of managing RA and the opportunities for providers to support them at each decision-making process. A patient-centred care approach is suggested to support female patients with RA in making reproductive and medication choices aligning with their individual desires, needs, and values. |
Association of acidic urine pH with impaired renal function in primary gout patients: a Chinese population-based cross-sectional study. Approximately half of gout subjects had acidic urine pH. Urine pH < 5.0 was associated with significantly increased nephrolithiasis, renal cyst, microhematuria, and proteinuria. The results support prospective clinical investigation of urinary alkalinization in selected gout patients with acidic urine pH. |
Characterizing memory T helper cells in patients with psoriasis, subclinical, or early psoriatic arthritis using a machine learning algorithm. Unsupervised clustering analysis revealed differences in circulating memory Th cells between psoriasis and PsA patients compared to HC; however, no specific subset was identified characterizing subclinical PsA patients. |
Non-criteria manifestations in primary antiphospholipid syndrome: a French multicenter retrospective cohort study. The presence of non-criteria features is important to consider, as they are associated with particular clinical and laboratory profiles, increased risk of relapse, and need for additional therapies. Prospective studies are necessary to better stratify the prognosis and the management of p-APS. |
Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases. This study provides the rationale for the possible innovative use of penfluridol as a newly identified small-molecule drug for TNFa-driven diseases, such as inflammatory arthritis and colitis. |
Prioritising referrals of individuals at-risk of RA: guidance based on results of a 10-year national primary care observational study. This is the largest prospective primary care study of individuals at risk of IA, and the first one to prospectively investigate the outcome of MSK symptoms in a large anti-CCP- cohort. High anti-CCP levels and pain in hands/feet indicated an increased likelihood of progression to IA. In patients with low anti-CCP level and no pain in the hands/feet, progression is unlikely. In anti-CCP- patients, those with hand or knee pain were at increased risk of progression. This study demonstrates that routinely available tests and joint symptoms provide useful discrimination that may be used to prioritise referrals to rheumatology and avoid a delayed diagnosis. |
Striking sex differences in magnetic resonance imaging findings in the sacroiliac joints in the population. Different factors were associated with the extent of SIJ BME in females and males. Most importantly, HLA-B27 was relevant only in males but not in females in whom a postpartal state was important. This finding may be relevant for the pathogenesis of axSpA. |
Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO. Patients on long-term TNFi treatment with a mean sustained low disease activity measures by ASDAS presented lower radiographic progression than those with active disease. |
| Arthritis Rheumatol |
Antibodies to cartilage oligomeric matrix protein are pathogenic in mice and may be clinically relevant in rheumatoid arthritis. We provide the structural basis for binding a pathogenic anti-COMP antibody to cartilage. The recognized epitope can be citrullinated and levels of antibodies to this epitope are elevated in RA patients and correlate with higher disease activity, implicating a pathogenic role of anti-COMP antibodies in a subset of RA patients. |
Antiphospholipid antibodies increase endometrial stromal cell decidualization, senescence and inflammation via TLR4, ROS and p38 MAP kinase signaling. These findings shed new light on the pathogenesis of pregnancy complications in women with aPL and underscore the benefit of heparin for preventing pregnancy loss in this high-risk population. |
Brain Structural Changes during Juvenile Fibromyalgia: Relationships with Pain, Fatigue and Functional Disability. Pain-related MCC reductions may be a structural hallmark of JFM, whereas alterations in regions involved in emotional, self-referential, and language-related processes may predict disease impact on patients' well-being. The partial overlap between juvenile and adult fibromyalgia findings strengthens the importance of early symptom identification and intervention to prevent the transition to adult forms of the disease. |
Haploinsufficiency of PSMD12 causes proteasome dysfunction and subclinical autoinflammation. PSMD12 haploinsufficiency causes a set of inflammation signatures besides neurodevelopmental disorders. Our work expands the genotype and phenotype spectrums of PRAAS, and makes a bridge between the almost exclusively inflammatory phenotypes in the majority of PRAAS patients to the almost exclusively neurodevelopmental phenotypea in previously reported Stankiewicz-Isidor syndrome (STISS) (OMIM 604450). |
LSD1 metabolically integrates osteoclast differentiation and inflammatory bone resorption through HIF-1a and E2F1. LSD1 metabolically regulates osteoclastogenesis in an inflammatory energy-demanding environment and provides new therapeutic strategies targeting osteoclasts against inflammatory arthritis including RA. |
Prevalence, Incidence, and Progression of Radiographic and Symptomatic Hand Osteoarthritis: The Osteoarthritis Initiative. Hand OA is a heterogeneous disease with complex differences by age, sex and race, hand symptoms and patterns of specific joints. Further research investigating the mechanisms behind these differences whether mechanical, metabolic, hormonal, or constitutional is warranted. |
| Rheumatology (Oxford) |
Clinical features and immune-related protein patterns of anti-MDA5 positive clinically amyopathic dermatomyositis Dutch patients. In this Dutch anti-MDA5 positive CADM cohort, one third of the patients died due to RPILD soon after diagnosis, which underlines the severity of this disease. In addition, we have found several possible pathways that are differentially regulated in RPILD vs no RPILD DM and healthy controls. These markers await further validation before clinical use. |
Disparities in the prevalence of clinical features between systemic juvenile idiopathic arthritis and adult-onset Still's disease. We found remarkable disparities in the prevalence of clinical manifestations between the two illnesses, which may partly depend on their classification by different criteria. |
Easy-BILAG: a new tool for simplified recording of SLE disease activity using BILAG-2004 index. Easy-BILAG facilitates more rapid and accurate scoring of BILAG-2004 across al clinical settings, which could improve patient care and biologics prescribing. Easy-BILAG should be adopted wherever BILAG-2004 assessment is required. |
Myositis-Specific Autoantibodies and QTc Changes by ECG in Idiopathic Inflammatory Myopathies. Presence of QTc abnormalities was as common in patients with IIM as in patients with SSc, including prolonged QTc seen in almost one fifth of the patients. Anti-Mi2, anti-Pl-7, and elevated CRP may serve as biomarkers for cardiac disease in IIM, but needs to be confirmed in a larger prospective study. |
Rates and predictors of methotrexate-related adverse events in patients with early rheumatoid arthritis: results from a nationwide UK study. AEs were common among patients over the first year of MTX, although most were not serious. Knowledge of the rates and factors associated with AEs occurrence are valuable when communicating risks prior to commencing MTX. This can help patients make informed decisions whether to start MTX, potentially increasing adherence to treatment. |
Plenty of the editorials are available as full text through the publisher website using the provided link
Letters to the editors and authors’ replies
all remaining publications eg case reports, images of the month, etc…
| Rheumatology (Oxford) |